UCL and GOSH paediatric centre

This centre is a unified Principal Treatment Centre, caring for aged 0-18 at Great Ormond Street Hospital and for those aged 18 and over at University College London Hospitals.

Centre overview

Our joint University College London (UCL) and Great Ormond Street Hospital (GOSH) paediatric and young adult experimental cancer medicine centre (ECMC) has well established infrastructure for early-phase clinical trials. It's made up of GOSH facilities and the Teenage Cancer Unit at UCL Hospitals UCLH) NHS Foundation Trust.

Both sites are supported by dedicated clinical research facilities and closely linked to preclinical research at the UCL Institute of Child Health and the UCL Cancer Institute.

The centre has a strong track record in immunotherapy focused early-phase research, participation in Innovative Therapies for Children with Cancer European Consortium (ITCC) studies, and close integration with our adult London UCLH ECMC to expand trial access. Facilities at both sites support patients and families travelling to London for trial participation.

There is also an adult centre at UCLH.

Expertise

  • solid tumours

  • haematology leukaemia

  • neuro-oncology brain tumours

  • immunology CAR T therapy

  • genomics

  • targeted agents

Key contacts

Navy blue icon indicating an adult's head and shoulders.

Darren Hargrave - Centre co-lead

Darren is Professor of Paediatric Neuro-oncology at UCL and Honorary Consultant Paediatric Oncologist at GOSH, where he leads the neuro-oncology and experimental therapeutics programme. He has extensive experience in leadership of clinical research teams and networks, translational research and development and coordination of clinical trials from first-in-child to randomised Phase 3 studies.

Sara Ghorashian.

Sara Ghorashian - Centre co-lead

Sara Ghorashian is a Clinical Associate Professor at UCL and Honorary Consultant Paediatric Haematologist at GOSH, where she leads the licensed CAR T cell service and a portfolio of commercial and academic CAR T cell studies. Her research group focuses on improving the optimisation of CAR T cell therapies for acute leukaemia and translating them into early-phase clinical studies.

Image of Lola Famakinwa.

Lola Famakinwa - Clinical trial coordinator / Centre business lead

Lola Famakinwa is a Senior Clinical Trial Associate with over a decade of experience in Haematology and Oncology clinical research. Lola is instrumental in the setup, management and close-out of phase 1 to 4 trials, supporting each study from initiation to completion. She oversees a portfolio of trials, ensuring they are delivered to the highest standards of quality, compliance and patient safety.

Image of Emily Baker.

Emily Baker - Research nurse

Emily Baker is an experienced cancer nurse, having worked in the speciality since 2002 and joining the clinical research team in 2018. Emily’s experience includes care of patients across all phases of clinical trials and helping to set up trials which include new ways of delivering therapy.

Contact details

Haematology/Oncology Trials Team

Level 3

Zayed Centre for Research

20 Guildford Street

London

WC1N 1DZ

Centre email:

gos-tr.haemoncresearch@nhs.net

Programme office email:

ecmcadmin@cancer.org.uk

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